Most planetary scientists will tell you the heyday of Venus exploration was more than a generation ago. That is about to change.

Two NASA missions are on track to launch to Venus in the early 2030s. The first, known as the Deep Atmosphere Venus Investigation of Noble gases, Chemistry, and Imaging (DAVINCI), is now scheduled for launch in December 2030, a year earlier than previously planned. DAVINCI will send a parachute-assisted descent probe through the atmosphere of Venus, returning the first direct images of the planet's surface since 1982. A second mission, Venus Emissivity, Radio science, InSAR, Topography, And Spectroscopy (VERITAS), will follow with a launch in November 2032 to map the Venusian surface by radar from orbit.

The European Space Agency is building another orbiter, Envision, for launch to Venus in 2032. The Venus armada might get started as soon as next year, when Rocket Lab aims to launch a privately funded probe to search for signs of organic material in the planet's clouds.

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A protein is a chain of amino acids held together by what are called peptide bonds. On their own, those bonds are extremely stable; they're estimated to have a half-life of several hundred years. But in Earth's environment, most proteins don't last nearly that long. That's because organisms have evolved a handful of ways to catalyze the break-up of peptide bonds, which have diversified into countless specialized protein-digesting enzymes. Proteases are everywhere and generally make short work of any proteins that find their way into the environment.

Now, researchers have basically short-circuited the diversification process, using AI-based protein design tools to take the catalytic core of two types of protease and replace the entire rest of the protein. The resulting enzymes could be tuned to cut specific proteins in half, and the researchers demonstrated their effectiveness by using them to cut proteins associated with neurological diseases.

Cutting proteins

The basic peptide bond isn't especially interesting-looking—it's what you get when you link an amino group to an acid, releasing a water molecule in the process. As their name implies, amino acids have both an amino and an acid group, allowing them to form peptide bonds on two sides of the amino acid. This is critical for building up the long chains found in proteins. (The amino acids also have side chains with distinctive chemistry, which gives a backbone specific properties.)

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